- 1803 - At U.S. purchase of Louisiana, the Apalachees consider moving to Texas but retreat instead to the backwoods of Louisiana.
- 1823 - U.S. surveyors visit San Luis in their search for a suitable location for the territorial capital.
- 1825 - San Luis is purchased by Robert Jameson and Benjamin Clements as part of the south half of Section 27.
- 1860 - San Luis first identified as the center of A.M. Randolph's plantation up for sale with a ten-room, two-story house with lodgings for 50 slaves.
- 1884 - Helen Dodd sells her two-thirds of the San Luis tract to Emile Dubois and Maximilian Berlitz but continued to live at the site.